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Apexigen was a clinical-stage biopharmaceutical company focused on discovering and developing innovative antibody therapeutics for oncology, acquired by Pyxis Oncology in 2023.

Last updated September 15, 2026

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Nov 4, 2026
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Nov 4, 2026

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Overview

Apexigen, Inc. was a clinical-stage biopharmaceutical company focused on discovering and developing innovative antibody therapeutics for oncology. In August 2023, Pyxis Oncology, Inc. (Nasdaq: PYXS) announced the successful completion of its acquisition of Apexigen in an all-stock transaction valued at approximately $10.7 million. The transaction added a validated antibody-discovery platform, a Phase 2 candidate and a royalty stream to Pyxis Oncology, and brought the CD40 agonist sotigalimab (renamed PYX-107) into the combined company's pipeline.

History

Apexigen, Inc. was a clinical-stage biopharmaceutical company focused on discovering and developing innovative antibody therapeutics for oncology. On August 23, 2023, Pyxis Oncology, Inc. (Nasdaq: PYXS) announced the successful completion of its acquisition of Apexigen in an all-stock transaction valued at approximately $10.7 million. The transaction added a validated antibody-discovery platform, a Phase 2 candidate and a royalty stream to Pyxis Oncology, and the combined company's platform included novel humanized antibody generation capabilities, an expanded library of linkers with improved stability, site-specific conjugation chemistries, and optimized payloads. The acquisition also brought the CD40 agonist sotigalimab, renamed PYX-107, into the combined company's pipeline.

Products and positioning

Clinical-stage biopharmaceutical company focused on discovering and developing innovative antibody therapeutics for oncology.

  • sotigalimab (PYX-107)

    A CD40 agonist described as a potentially first- and best-in-class candidate with demonstrated anti-cancer activity in patients who previously progressed on PD-(L)1 inhibitors; renamed PYX-107 following the acquisition.

Recent events

  • Reported

    Apexigen appoints Gordon Ringold to its board[3]

    Apexigen announced the appointment of Gordon Ringold, Ph.D., to its Board of Directors.

  • Reported

    Apexigen appoints Herb Cross to its board[4]

    Apexigen announced that Herb C. Cross joined its Board of Directors as an independent director and would serve as chair of the board’s Audit Committee.

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