E-Phy-Science

E-Phy-Science is a French service company and contract research organization (CRO) specialized in in-vivo and in-vitro electrophysiological assays. Based in the Bioparc of Sophia Antipolis in Biot, near Nice in southeastern France, the company positions itself as a specialized platform that gathers in-vivo, ex-vivo and in-vitro electrophysiology capabilities under one roof. Its stated purpose is to support pharmaceutical and biotechnology clients developing programs in central nervous system (CNS) disorders, helping them increase the chances of success of their R&D projects, improve product reliability and speed up time to market. The company's scientific focus is on the electrical activity of the brain and nervous system. Its team of electrophysiologists describes in-depth knowledge and expertise in models of neurological and psychiatric disorders, in particular Alzheimer's disease, depression and anxiety, epilepsy, Huntington's disease, Parkinson's disease, schizophrenia, stroke and PTSD. E-Phy-Science states that it is backed by a Scientific Advisory Board presided by Professor Michel Lazdunski and comprised of thought-leading experts from industry and academia. E-Phy-Science offers a range of services covering toxicology and pharmacokinetics, in-vivo electrophysiology, in-vitro electrophysiology, behavioral tests and electrophysiology workshops. Its in-vivo work spans freely moving and anesthetized animals, field potential and multi-unit recordings, extracellular single-electrode and multi-electrode recordings (including 8-channel silicon probes), electroencephalogram (EEG), signal analysis such as time-frequency maps, fast-Fourier transform and coherence, spike sorting and field potential-spike relationship analysis, plasticity measurement (short-term and long-term potentiation and depression), plasticity induction via high- and low-frequency stimulation or behavioral paradigms such as fear extinction, fear conditioning and associative learning, and brain perturbations including acute and chronic drug injection under stereotaxic control and brain lesions. The company covers needs from moving animals to single-channel analysis. As a privately held, founder- or investor-backed service company rather than a listed corporation, E-Phy-Science operates primarily as a business-to-business research partner for the life sciences industry. Its clients are typically pharmaceutical companies, biotechnology firms and academic or translational research groups that need outsourced, high-level electrophysiology expertise. The company is reachable through its Sophia Antipolis offices and maintains a LinkedIn presence and an RSS feed alongside its website.

E-Phy-Science is a French service company specialized in in-vivo and in-vitro electrophysiological assays. It is located in the Bioparc of Sophia Antipolis, in Biot, France, within the Sophia Antipolis technology park near Nice. The company was established to serve the central nervous system (CNS) drug development market by providing outsourced electrophysiology expertise that many pharmaceutical and biotechnology organizations do not maintain in-house. From its founding, E-Phy-Science has built its identity around a single integrated platform that gathers in-vivo and in-vitro electrophysiological assays together. According to the company, this combination allows its team to offer clients a complete range of studies. These assays can reveal specific abnormalities in many genetic models of human brain disease, as well as the effect of new molecules on normal brain functions, providing insights for new therapies and for understanding the mechanisms of brain diseases. The company states that it covers all electrophysiological analysis needs, from moving animals to single-channel analysis. The company has assembled a team of electrophysiologists with in-depth knowledge and expertise in models of neurological disorders, in particular Alzheimer's disease, depression and anxiety, epilepsy, Huntington's disease, Parkinson's disease, schizophrenia, stroke and PTSD. It is backed by a Scientific Advisory Board presided by Professor Michel Lazdunski and comprised of thought-leading experts from industry and academia, a structure intended to reinforce scientific credibility with pharmaceutical clients. Over time, E-Phy-Science has expanded its service catalog beyond core electrophysiology. Its published services now include toxicology and pharmacokinetics, in-vivo electrophysiology, in-vitro electrophysiology, behavioral tests and electrophysiology workshops. Its in-vivo offering covers freely moving and anesthetized animals, field potential and multi-unit recordings, extracellular single-electrode recordings, extracellular multi-electrode recordings using 8-channel silicon probes, electroencephalogram (EEG), and a broad set of signal-analysis methods including time-frequency maps, fast-Fourier transform, coherence, spike sorting and field potential-spike relationship analysis. It also provides plasticity measurement and induction, including short-term and long-term potentiation and depression, high-frequency and low-frequency stimulation, and behavioral induction of plasticity such as fear extinction, fear conditioning and associative learning. Brain perturbation services include acute and chronic injection of drugs under stereotaxic control and brain lesions. The company markets itself directly to organizations developing CNS disorder programs, offering to help increase their chances of success, improve product reliability and speed up time to market. It maintains a website with service pages, downloadable leaflets summarizing its in-vivo and in-vitro electrophysiological services, a LinkedIn presence and an RSS feed. It is a privately held company rather than a listed one, and it operates from Sophia Antipolis in France.

Specialized, high-expertise electrophysiology CRO platform for CNS drug development, combining in-vivo, ex-vivo and in-vitro assays with scientific advisory support.

• In-vivo electrophysiology

  Freely moving and anesthetized animals; field potential and multi-unit recordings; extracellular single- and multi-electrode recordings (8-channel silicon probe); EEG; signal analysis; plasticity measurement and induction; brain perturbations.

• In-vitro electrophysiology

  In-vitro electrophysiological assays offered as part of the integrated platform, from moving animals to single-channel analysis.

• Toxicology & Pharmacokinetics

  Toxicology and pharmacokinetics services supporting CNS drug development programs.

• Behavioral tests

  Behavioral testing services, including behavioral induction of plasticity such as fear extinction, fear conditioning and associative learning.

• Electrophysiology Workshop

  Workshop service offering electrophysiology training or expert support.

1. 1E PHY SCIENCE - In Vivo Ex Vivo Electrophysiology platforme-phy-science.com
2. 2Company - E PHY SCIENCEe-phy-science.com
3. 3Services - E PHY SCIENCEe-phy-science.com
4. 4IN VIVO Electrophysiology - E PHY SCIENCEe-phy-science.com
5. 5E-Phy-Science (France) - Wikidatawikidata.org