Innotope GmbH

Innotope GmbH is an Austrian life-sciences chemistry company founded in 2020 as a spin-off from the University of Innsbruck. Based in Innsbruck, it specialises in stable isotope labelling of nucleic acids, producing 13C/15N/2H-labelled RNA phosphoramidites and triphosphates that allow researchers to create tailor-made RNA oligonucleotides with optimised isotope patterns for NMR and mass spectrometry applications. The company positions itself as a partner for both academic research groups and industrial R&D units, emphasising high quality and Austrian manufacturing. Innotope's product portfolio has expanded beyond labelled RNA building blocks. It now includes "heavy" modified nucleotide and nucleoside standards for mass spectrometry, with a focus on heavy epigenetic modifiers used to study transient modifications in messenger RNAs (RNA epigenetics). The company also offers custom small-molecule synthesis services, drawing on its organic synthesis expertise, and a custom oligonucleotide synthesis service that leverages its labelled phosphoramidites and triphosphates. A distinctive product is Cellolyte, an NMR solvent system for cellulosic materials, known in the literature as [P4444][OAc]:DMSO-d6 (w/w 1:4), which enables solution-state NMR analysis of poorly soluble crystalline cellulose. The founding team combines academic and industrial experience. Felix Nussbaumer developed synthetic methods for high-purity RNA and DNA phosphoramidites and triphosphates during his Master's and PhD studies. Christoph Kreutz is an Associate Professor at the Institute of Organic Chemistry, University of Innsbruck, whose research focuses on chemo-enzymatic stable isotope labelling of nucleic acids for NMR and mass spectrometry. Michael Juen obtained his PhD in nucleic acid structural biology in 2019 and subsequently joined Roche Diagnostics. The company operates from Botanikerstrasse 11/3 in Innsbruck, with laboratory facilities at the Center for Molecular Biosciences Innsbruck (Innrain 80/82). As a privately held startup, Innotope serves a niche market at the intersection of synthetic chemistry, structural biology, and analytical chemistry. Its customers are primarily research laboratories and pharmaceutical or biotechnology companies needing labelled nucleotides and custom oligonucleotides. The company's stated mission is to accelerate innovation and business for its partners by providing high-quality, made-in-Austria chemical tools.

Innotope GmbH was founded in 2020 as a spin-off from the University of Innsbruck, Austria. The company emerged from research activities at the Institute of Organic Chemistry, where co-founder Christoph Kreutz, an Associate Professor, had spent the previous decade focusing on chemo-enzymatic stable isotope labelling of nucleic acids for NMR spectroscopy and later mass spectrometry. His work was published in journals such as Nature Structural and Molecular Biology and the Journal of the American Chemical Society. The founding team also includes Felix Nussbaumer, who during his Master's and PhD studies developed highly efficient and robust synthetic methods to produce high-purity RNA and DNA phosphoramidites and triphosphates for chemical and enzymatic nucleic acid production. Michael Juen, who obtained his PhD in nucleic acid structural biology in 2019 and then joined Roche Diagnostics, completes the founding group. Initially, Innotope provided stable isotope labelled RNA phosphoramidites and triphosphates mainly for academic research. The company has since expanded its product portfolio to include heavy modified nucleotide and nucleoside standards for mass spectrometric applications, focusing on heavy epigenetic modifiers. It also offers custom small molecule synthesis and custom oligonucleotide synthesis services. A notable product is Cellolyte, an NMR solvent for cellulosic materials, known in the literature as [P4444][OAc]:DMSO-d6 (w/w 1:4). The company operates from Botanikerstrasse 11/3 in Innsbruck, with laboratory facilities at the Center for Molecular Biosciences Innsbruck (Innrain 80/82). It positions itself as a strong partner for both academic research and industrial research and development, emphasising high quality and Austrian manufacturing. As of the available information, Innotope remains a privately held startup.

• 2020

  Founded as a spin-off from the University of Innsbruck.

• Expanded product portfolio to include heavy modified nucleotide and nucleoside standards for mass spectrometry.

• Launched Cellolyte, an NMR solvent for cellulosic materials.

High-quality, made-in-Austria supplier of stable isotope labeled nucleic acid building blocks and analytical standards for academic and industrial research.

• 13C/15N/2H-stable isotope labeled RNA phosphoramidites

  Building blocks for tailor-made RNA oligonucleotides with optimized isotope labeling patterns for NMR and mass spectrometry.

• 13C/15N/2H-stable isotope labeled RNA triphosphates

  Triphosphates for enzymatic nucleic acid production with stable isotope labels.

• Heavy modified nucleotide and nucleoside standards

  High-purity mass spectrometry standards, including 2'-O-Methyl(D3)-uridine, -cytidine, -adenosine, -guanosine, and 5-Methyl(D3)-cytidine, for RNA epigenetics research.

• Cellolyte

  NMR solvent for cellulosic materials, known as [P4444][OAc]:DMSO-d6 (w/w 1:4), enabling solution-state NMR analysis of crystalline cellulose.

• Custom small molecule synthesis

  Custom synthesis service leveraging profound organic synthesis knowledge.

• Custom oligonucleotide synthesis

  Tailor-made RNA oligonucleotides with stable isotope labeling patterns for NMR assignment, RNA relaxation NMR, and NMR of RNA modifications.

1. 1Innotope official website homepageinnotope.at
2. 2About Innotopeinnotope.at
3. 3Cellolyteinnotope.at
4. 4Mass Spectrometry Standardsinnotope.at
5. 5Wikidata entry for Innotope GmbHwikidata.org