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International Apatite Institute Co., Ltd.

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A Japanese university-origin venture developing and selling apatite-based dental, cosmetic, and health products.

Last updated September 28, 2026

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Overview

International Apatite Institute Co., Ltd. (IAI) is a small Japanese company based in Chiyoda-ku, Tokyo, dedicated to the research, development, and commercialization of apatite-related materials. Apatite, particularly hydroxyapatite, is a calcium phosphate mineral that is the main inorganic component of bone and teeth; IAI applies it to dental care, cosmetics, health foods, quasi-drugs, and industrial products. The company was originally established in November 1995 as the International Apatite Institute, and in April 2002 it was registered as a university-origin venture company (有限会社国際アパタイト研究所). After an absorption-type merger in April 2006, the current stock company, 株式会社国際アパタイト研究所, was re-established in May 2010. Its representative director is Dr. Hideki Aoki, a researcher often referred to as 'Mr. Apatite' in Japan. The company's business scope includes the development, manufacture, and sale of apatite-related medical devices, quasi-drugs, health foods, cosmetics, and industrial products; the publication and sale of apatite-related books and magazines; the operation of academic societies and research groups; and the planning and management of seminars and training courses. Its product line features hydroxyapatite-based toothpaste such as Apamedical and the Apabeauty series, a facial cleansing powder (New Apabeauty), and an apatite-containing cigarette called Apaleaf (not for sale). The company also runs the 'Apatite Salon' at its office, a discussion space where visitors can talk about apatite research and applications over coffee or wine, and it organizes study sessions and courses on dental implant science. With capital of 10 million yen, IAI remains a private, niche player in the Japanese apatite-related market.

History

The International Apatite Institute (IAI) was first established in November 1995 as a research organization focused on apatite, a family of phosphate minerals that includes hydroxyapatite, the main mineral component of teeth and bones. On April 16, 2002, it was registered as a university-origin venture company under the name 有限会社国際アパタイト研究所 (Yugen Kaisha International Apatite Institute). This legal entity underwent an absorption-type merger on April 20, 2006. The current stock company, 株式会社国際アパタイト研究所 (Kabushiki Kaisha International Apatite Institute), was re-established in May 2010. The company is led by Dr. Hideki Aoki, a prominent researcher in apatite science who is sometimes called 'Mr. Apatite' in Japan. Under his direction, IAI has developed and commercialized a range of apatite-based products, including hydroxyapatite toothpaste (Apamedical, Apabeauty), a facial cleansing powder (New Apabeauty), and an experimental apatite-containing cigarette (Apaleaf, not for sale). The company also engages in publishing apatite-related books and magazines, operating academic societies and research groups, and organizing seminars and training courses, such as those on dental implant science. In recent years, IAI opened the 'Apatite Salon' at its Tokyo office, a space for open discussion on apatite research and applications, where visitors can enjoy coffee or wine. The company remains a small, privately held enterprise with capital of 10 million yen, headquartered in Chiyoda-ku, Tokyo.

  • 2010

    Kabushiki Kaisha International Apatite Institute re-established.

  • 2006

    Absorption-type merger.

  • 2002

    Registered as a university-origin venture company under the name Yugen Kaisha International Apatite Institute.

  • 1995

    International Apatite Institute (IAI) established.

Products and positioning

Specialist in apatite (hydroxyapatite) applications for dental, cosmetic, and health products, leveraging university research and the expertise of Dr. Hideki Aoki.

  • Dental Apabeauty

    Toothpaste with high nano-hydroxyapatite content; promotes dental health and beauty, removes plaque, and does not damage tooth enamel. Coming soon.

  • New Apabeauty

    Facial cleansing powder containing high-purity microcrystalline hydroxyapatite; cleanses skin, removes dark pores and dead keratin.

  • Apamedical

    Toothpaste with high-purity microcrystalline hydroxyapatite; whitens teeth, removes plaque, and does not damage tooth enamel.

  • Apaleaf

    Apatite-containing cigarette; not for sale.

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