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Regenexx is a licensed network of physicians providing non-surgical, image-guided interventional orthopedic treatments as an alternative to orthopedic surgery.

Last updated September 16, 2026

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Nov 4, 2026
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Overview

Regenexx is described as the "Trusted Alternative to Orthopedic Surgery," with over 100 locations in its licensed network treating dozens of orthopedic conditions without surgery. Physicians in the licensed Regenexx network provide non-surgical options for individuals experiencing pain related to orthopedic issues, including osteoarthritis, joint injuries, spine pain, overuse conditions, and common sports injuries, using proprietary, research-based methods and patented protocol to prepare and precisely apply injectates. The company was founded in 2005 by Dr. Chris Centeno and Dr. John Schultz, who pioneered the specialty of Interventional Orthopedics and were the first in the world to apply stem cells from bone marrow concentrate to treat many orthopedic injuries.

History

In 2005, Dr. Chris Centeno and Dr. John Schultz, physicians in a small two-person pain management clinic in Colorado, pioneered the specialty of Interventional Orthopedics. They were the first in the world to apply stem cells from bone marrow concentrate to treat many orthopedic injuries. Two years later, they completed a two-year, IRB-approved research study of the use of both culture-expanded and same-day stem cells to treat knee and hip arthritis and low-back degenerative disc disease. Regenexx continuously innovates through research, development, and training, and has introduced many of the processing and treatment techniques used in the field today. The company has also published a large part of all research on the use of bone marrow concentrate for the treatment of orthopedic injuries. In 2022, Regenexx published mid-term results of its randomized controlled trial. In 2023, the Regenexx network of licensed physicians reached over 100 locations. In 2024, Regenexx announced Dr. Philippe Hernigou as New Medical Director of Clinical Research. In 2025, the Regenexx Corporate Program serves over 2,000 self-funded employers to reduce their MSK costs by adding Regenexx as a benefit to their health plan.

Products and positioning

Trusted Alternative to Orthopedic Surgery

  • Regenexx injectates

    Proprietary, research-based injectates prepared and precisely applied to support the body's natural healing processes.

  • Bone marrow concentrate procedures

    Regenexx lab processing routinely achieves 20x concentration of stem cell-containing bone marrow.

Recent events

  • Reported

    Gilsbar and Regenexx announced a partnership offering orthopedic treatment alternatives[6]

    Gilsbar announced a partnership with Regenexx that gives Gilsbar's self-funded clients access to Regenexx procedures and offers non-surgical alternatives for orthopedic conditions.

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